We can replace −Q charge at origin by +Q and −2Q.
Now due to +Q charge at every corner of cube. Electric field at center of cube is zero so now net electric field at center is only due to −2Q charge at origin.
E=r3kqr=4πϵ0(2a3)31(−2Q)2a(x^+y^+z^)
E=33πa2ϵ0−2Q(x^+y^+z^)