Formyl-met-tRNA is formed by addition of methionine to tRNA fMet (formyl-methionine specifictRNA) by the fMet-tRNA synthetase to produce methioninetRNA and then transfer of formyl group from N10 formyl tetrahydrofolate to the amino group of the Met residue to produce N-formyl methionine tRNA. Binding of 30 S ribosomal subunit to two initiation factors, IF-1 and IF-3 initiates translation. Factor IF-3 prevents the 30 S and 50 S subunits from combining prematurely and mediated binding of mRNA to 30 S subunit. This is followed by binding of complex consisting of the 30 S ribosomal subunit, IF-3, and mRNA with the initiating formyl met tRNA in presence of GTP-bound IF-2. The pairing of anticodon of tRNA with the mRNAs initiation codon induces binding of 50 S ribosomal subunit. Thus, association of 30 S mRNA with formyl-met-tRNA required GTP.
During translation initiation in prokaryotes, a GTP molecule is needed in:
NEET UG 2003 — Zoology Molecular Basis of Inheritance
During translation initiation in prokaryotes, a GTP molecule is needed in:
Held on 30 Apr 2003 · Verified 9 Jul 2026.
Options
- A
formation of formyl-met- t RNA
- B
binding of 30 S subunit of ribosome with m RNA
- C
association of 30 SmRNA with formyl-mel- t RNA
- D
association of 50 S subunit of ribosome with initiation complex
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