Genetic equilibrium means that the frequency of occurrence of alleles of a gene is supposed to remain fixed and even remain the same through generations. Gene frequencies tend to remain constant from generation to generation when disturbing factors are not present. Factors that disturb the natural equilibrium of gene frequencies include mutation, migration (or gene flow), random genetic drift, and natural selection. Related Theory Random mating involves the mating of individuals regardless of any physical, genetic or social preference. In other words, the mating between two organisms is not influenced by any environmental, hereditary or social interaction. Hence, potential mates have an equal chance of being selected.