The nervous system and endocrine system both use chemical messengers to signal cells, but each has a different transmission speed. The signals from nervous system stimulates the endocrine system, which inturn target the specific organ to function. Related Theory Along with the nervous system, the endocrine system coordinates the body's functions to maintain homeostasis during rest and exercise. The nervous and endocrine systems also work together to initiate and control movement, and all the physiological processes movement involves.