In the resting nerve fibre, the cytoplasm inside the axon has a high concentration of K+and a low concentration of Na+in contrast to the fluid outside the axon. Thus, if diffusion occurs the through concentration gradient Na+enters the fibre. Related Theory The sodium-potassium pump is a mechanism of active transport that moves sodium ions out of cells and potassium ions into cells. The sodium-potassium pump moves both ions from areas of lower to higher concentration, using energy in ATP and carrier proteins in the cell membrane. Sodium is the principal ion in the fluid outside of cells, and potassium is the principal ion in the fluid inside of cells. These differences in concentration create an electrical gradient across the cell membrane, called resting potential.