As a person moves up a hill the pO2 and total atmospheric pressure decreases. Decrease in pO2 due to increasing altitude, stimulates the JG-cells of kidney to secrete erythropoietin hormone, increasing the number of RBCs (polycythemia) to compensate the supply of O2. At higher altitude, haemoglobin has lower binding affinity to O2 because the primary factor responsible for binding is p2, which decreases at higher altitude.
People who have migrated from the planes to an area adjoining Rohtang Pass about six months back
NEET UG 2012 — Zoology Body Fluids and Circulation
2012mcqmedium
People who have migrated from the planes to an area adjoining Rohtang Pass about six months back
Official previous-year question
Held on 30 Apr 2012 · Verified 9 Jul 2026.
Options
- A
have more RBCs and their haemoglobin has a lower binding affinity to O2
- B
are not physically fit to play games like football
- C
suffer from altitude sickness with symptoms like nausea, fatigue, etc.
- D
have the usual RBC count but their haemoglobin has very high binding affinuty to O2
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