Correct Option
The correct matching of List-I with List-II is as follows:
- A. Discovery of transduction and conjugation in bacteria: Joshua Lederberg, along with Norton Zinder, discovered transduction in bacteria. Lederberg also made significant contributions to the discovery of bacterial conjugation.
- B. Establishing the sex-linked inheritance: Thomas Hunt Morgan established the principle of sex-linked inheritance through his experiments with the fruit fly, Drosophila melanogaster, demonstrating the linkage of specific traits, such as eye colour, to sex chromosomes.
- C. Isolation of DNA polymerase from E. coli: Arthur Kornberg successfully isolated DNA polymerase I from the bacterium E. coli, a pivotal achievement in understanding DNA replication.
- D. Establishing the complete genetic code: Har Gobind Khorana, along with Marshall Nirenberg and Robert Holley, made crucial contributions to deciphering the genetic code, elucidating how sequences of three nucleotide bases (codons) specify particular amino acids.
Therefore, the correct sequence is A-3, B-4, C-2, D-1, which corresponds to option 4 (3421).
Incorrect Options
- Option 1 (4321): This option incorrectly matches A with Morgan (4) and B with Lederberg (3).
- Option 2 (3415): This option incorrectly matches C with Khurana (1) and D with Ochoa (5).
- Option 3 (4315): This option incorrectly matches A with Morgan (4) and B with Lederberg (3). It also incorrectly matches C with Khurana (1) and D with Ochoa (5).