The given integral can be written as
I=∫(2+3x−2+x−4)43.x−3+2x−5dx
(Dividing x16 to both numerator and denominator),
Let, 2+3x−2+x−4=t
⇒(−6x−3−4x−5)dx=dt
⇒−2(3x−3+2x−5)dx=dt
∴I=−21∫t4dt=−21(−4+1t−4+1)=61(t31)+C, where C is the constant of integration.
=6(2+3x−2+x−4)31+C=6(2x4+3x2+1)3x12+C