We know that (1−x)100=C0100−C1100⋅x+C2100⋅x2−.......−C49100⋅x49+.......+C100100⋅x100
Now let, the sum of first fifty coefficients be S.
⇒S=C0100−C1100+C2100−.......−C49100
Let us substitute x=1 in the expansion.
⇒(1−1)100=C0100−C1100⋅1+C2100⋅12−.......−C49100⋅149+.......+C100100⋅1100
⇒0=C0100−C1100+C2100−.......−C49100+C50100−C51100+C52100.......+C100100
There are total of 101 terms and the middle term is T51=C50100.
As Crn=Cn−rn
⇒0=C0100−C1100+C2100−.......−C49100+C50100−C49100+C48100.......+C0100
⇒0=C50100+C0100−C1100+C2100−.......−C49100−C49100+C48100.......+C0100
⇒0=C50100+2(C0100−C1100+C2100−.......−C49100)
⇒−2C50100=(C0100−C1100+C2100−.......−C49100)
⇒C0100−C1100+C2100−.......−C49100=−2C50100
Therefore, the required answer is −2C50100=−21×50100C4999=−C4999.