Given: 2x−1=3y−2=4z−3
Let, P≡(2,3,5) and R≡(α,β,γ).

Now, direction ratio of PR=α−2,β−3,γ−5
And the line 2x−1=3y−2=4z−3 will be perpendicular,
So, using perpendicular condition we get,
⇒(α−2)×2+(β−3)×3+(γ−5)×4=0
⇒2α−4+3β−9+4γ−20=0
⇒∣2α+3β+4γ∣=33