The correct option is Dura mater.
Explanation
The human brain and spinal cord are enclosed and protected by three distinct connective tissue membranes known collectively as the meninges. These layers provide physical protection and contain the cerebrospinal fluid (CSF).
- Dura mater: This is the outermost meningeal layer. It is a thick, tough, and fibrous membrane that lines the inner surface of the skull bones. Its primary function is to provide strong protection to the brain.
- Arachnoid mater: This is the middle layer, situated between the dura mater and the pia mater. It has a spider-web-like structure. The space beneath this layer, known as the subarachnoid space, contains cerebrospinal fluid.
- Pia mater: This is the innermost layer. It is a delicate, thin, and highly vascularized membrane that adheres closely to the surface of the brain, following its contours (gyri and sulci).
- Perineurium: This is incorrect in this context. The perineurium is a connective tissue sheath that surrounds bundles of nerve fibers (fascicles) in the peripheral nervous system, not the central nervous system.
Key Takeaway: The arrangement of the meninges from the outside (skull) to the inside (brain tissue) is Dura mater → Arachnoid mater → Pia mater.