The correct option is 1 only
Explanation
Acromegaly is a hormonal disorder caused by the overproduction of Growth Hormone (GH) by the pituitary gland.
- Statement 1 is Correct: Acromegaly results from excess secretion of Growth Hormone in adults, typically during middle age. This distinguishes it from Gigantism, which occurs when excess GH is secreted in children before the closure of epiphyseal plates (growth plates) in bones.
- Statement 2 is Incorrect: The condition is strongly associated with physical disfigurement. Excess GH in adults leads to the enlargement of bones in the face, hands, and feet. Common features include a protruding lower jaw, thickened lips, and coarse facial features. If untreated, it can lead to severe complications and premature death.
- Statement 3 is Incorrect: Acromegaly is difficult to diagnose in its early stages. The physical changes occur gradually over many years, making them subtle and often unnoticed by the patient or their family until the condition is advanced.
Key Takeaway: Excess Growth Hormone causes Gigantism in children (before bone fusion) and Acromegaly in adults (after bone fusion). Acromegaly is characterized by the enlargement of peripheral body parts and is often diagnosed late due to its slow progression.