Examining the prime factorization of each number:
161=7×23
185=5×37
253=11×23
299=13×23
The numbers 161, 253, and 299 all share a common prime factor of 23.
161=7×23
253=11×23
299=13×23
The number 185 is the only one that does not have 23 as a prime factor.
185=5×37
Therefore, 185 is the odd one out.
The correct answer is Option 2.