Option 1 -> Creates awkward placement of "and personal relationship with God" before "of mankind in his everyday life."
Option 2 -> Starts with a verb without a subject, making the sentence grammatically incorrect.
Option 3 -> Forms a logical flow: subject (B) + verb phrase (A) + object continuation (D) + additional element (C), creating a complete, coherent sentence.
Option 4 -> Begins with a prepositional phrase fragment, disrupting the natural sentence structure.
Hence, Option 3: (B), (A), (D), (C) -> This arrangement creates the grammatically correct and meaningful sentence: "His famous work on 'Humanism' primarily stresses the importance and supreme value of mankind in his everyday life and personal relationship with God." The subject-verb-object structure flows naturally with proper modifiers in place. -> correct