The word OFFICE contains 6 letters: O, F, F, I, C, E
Vowels: O, I, E (3 vowels, all different)
Consonants: F, F, C (3 consonants, F repeats twice)
To find arrangements where vowels never come together:
Vowels never together = Total arrangements - Vowels always together
The word has 6 letters with F repeating twice.
Total arrangements =2!6!
=2720
=360
Treat all vowels (O, I, E) as one single block [OIE].
The units to arrange are: [OIE], F, F, C (4 units with F repeating twice)
Arrangements of these 4 units =2!4!
=224
=12
Arrangements of vowels within the block =3!
=6
Total arrangements with vowels together =12×6
=72
Arrangements where vowels never come together =360−72
=288
Therefore, the answer is 288.